Dose level was assigned using TITE-CRM (Time-to-Event Continual Reassessment Method) with the target dose-limiting toxicity (DLT) rate set to 0.25.\n\nResults: Fifty patients were accrued. DLTs were observed in 11 patients: G3/4 anorexia, nausea, vomiting, and/or dehydration (7); duodenal bleed (3); duodenal perforation

(1). The recommended dose is 55 Gy, producing a probability of DLT of 0.24. The 2-year FFLP is 59% (95% confidence interval [CI]: 32-79). Median and 2-year overall survival are 14.8 months (95% CI: 12.6-22.2) and 30% (95% CI 17-45). Twelve GSK690693 chemical structure patients underwent resection (10 R0, 2 R1) and survived a median of 32 months.\n\nConclusions: High-dose radiation therapy with concurrent FDR-G can be delivered safely. The encouraging efficacy data suggest that outcome may be improved in unresectable patients through intensification of local therapy. (C) 2012 Elsevier Inc.”
“Objective: To describe the geographical distribution of dengue fever cases in flooded areas of Villahermosa, Tabasco, in 2010. Methods: Cross-sectional, descriptive study. Universe: Colonies with antecedents of flooding during the inundation of the State, located in Villahermosa, Tabasco: Gaviotas Norte, Gaviotas Sur, La Manga 1th Section, La Manga 2nd Section and La Manga 3th Section. Convenience sample find more without randomization. Variables:

location, dengue fever case. Analysis: descriptive statistic. Software: SPSS version 11.0. Results: 540 individuals were included. The distribution was: Gaviotas Norte, 36.1%;

Gaviotas Sur, 24.8%; La Manga 1th Section, 13.8%; La Manga 2nd Section, 13.2%; and La Manga 3th Section, 12.1%. We found three cases with positive serology of IgG (0.6%) and five cases of positive IgM (0.9%). The geographical distribution was associated with the proximity to two water bodies: Rio Grijalva and Laguna El Encanto. Conclusions: It is necessary to reinforce preventive interventions in the proximity of bodies of fresh water.”
“Metastasis is responsible for most cancer deaths but it remains a poorly understood process. Recent evidence has emerged that death-associated protein kinase (DAPK) is a candidate of metastasis suppressor. DAPK downregulation Selleck GSK923295 or inactivation has been observed in a number of metastatic cancers through epigenetic, transcriptional, post-transcriptional, or post-translational mechanism. In certain cases, DAPK downregulation correlates with metastatic recurrence. Animal studies further show that DAPK impedes both early-stage and late-stage metastatic process, which suggests that DAPK possesses multiple mechanisms to suppress metastasis. Cell-based studies revealed that DAPK mediates several types of cell death, including apoptosis, autophagic death and necrosis, depending on death stimuli and cell context.