These findings extend the range of nonhematologic cancers associated with chemotherapy and add to the evidence that the combination of radiotherapy and chemotherapy can lead to especially large risks.”
“Objective: To analyse the Na content and labelling of processed and ultra-processed food products marketed in Brazil. Design: Cross-sectional

study. Setting: A large supermarket in Florianopolis, southern Brazil. Subjects: Ingredient lists and Na information on nutrition labels of all processed and ultra-processed pre-prepared meals and prepared ingredients, used in lunch or dinner, available for sale in the supermarket. Results: The study analysed 1416 products, distributed into seven groups and forty-one subgroups. Five products

did not have Na information. Most products (58.8 %; 95 % CI 55.4, 62.2 %) had MEK pathway high Na content ( bigger than 600 mg/100 g). In 78.0% of the subgroups, variation in Na content was at least twofold between similar products with high and low Na levels, reaching 634-fold difference in the ‘garnishes and others’ subgroup. More than half of the products (52.0%; 95% CI 48.2, 55.6 %) had at least one Na-containing food additive. There was no relationship between the appearance of salt on the Rigosertib manufacturer ingredients list (first to third position on the list) and a product’s Na content (high, medium or low; P = 0.08). Conclusions: Most food products had high Na content, with great variation between similar products, which presents new evidence for reformulation opportunities. There were inconsistencies in Na labelling, such as lack of nutritional information and incomplete ingredient descriptions. The position of salt on the ingredients list did not facilitate the identification of high-Na foods. We therefore recommend a reduction in Na in these products and a review of Brazilian legislation.”
“Melanoma is an aggressive cancer that is highly resistance to therapies once metastasized. We studied microRNA

( miRNA) expression in clinical melanoma subtypes and evaluated different miRNA signatures in the background of gain of function somatic and inherited mutations associated with melanoma. Total RNA from 42 patient derived LXH254 clinical trial primary melanoma cell lines and three independent normal primary melanocyte cell cultures was evaluated by miRNA array. MiRNA expression was then analyzed comparing subtypes and additional clinicopathologic criteria including somatic mutations. The prevalence and association of an inherited variant in a miRNA binding site in the 3′UTR of the KRAS oncogene, referred to as the KRAS-variant, was also evaluated. We show that seven miRNAs, miR-142-3p, miR-486, miR-214, miR-218, miR-362, miR-650 and miR-31, were significantly correlated with acral as compared to non-acral melanomas ( p < 0.04).